ISO TS 04971-2023.docx

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1、TECHNICA1.SPECIFICATIONISO/TS4971editionFirst2O23-O6Nanotechno1.ogiesPerformanceeva1.uationofnanosuspensionscontainingc1.aynanop1.atesforquorumquenchingNanotechno1.ogies-Eva1.uationdesperformancesdesnanosuspensionsdenanofeui1.1.etsd,argi1.epourIequorumquenchingISO2023COPYRIGHTPROTECTEDDOCUMENTISO202

2、3IUirhM*hedbdi1.iUedotherwiseupdhi.or啪UIBndttaeDmkfifiHipB1.andonnet8CH-1214Vernier,GenevaPhone：M1.22749O1.11觥ftte:丽丽BQrgPub1.ishedinSwitzer1.andAnnexA(informative)Re1.ationshipbetweenc1.aynanop1.atecharacteristicsandantibacteria1.performanceA.1.Genera1.Natura1.1.yabundantc1.ays,suchasmontmori1.1.on

3、ite,ha1.1.oysiteandirao!ine,genera1.1.yhavea1.ame1.1.arehajQiiboift!i1piha(roIiiiiuind1.ignnicp1.atcsandandnnoiibeofos1.HceAttfnectt)ftHtndt1.hnkfvouhih;efficacyforinhibitingbacteria1.activity.Ingenera1.,theefficacyisattributedtotheirhighspecificsurfacearea,surfacechargesandfinedispersioninaqueoussu

4、spension,whichrendertheattractionA4s帕rHE照她也酣径由胡驮*HS网融出ib般3福箱MM1.商速喻做OOthen招SKQ观部耿ypefort1.f1.kMi圈1.,w起W玳靛d1.威?W即mens粉mayaffectthespacingen1.argementandsurfaceexposure.13Forexamp1.e,thespecificsurfaceareaofmontmori1.1.onite,exfo1.iatedmontmori1.1.onite,micaandexfo1.iatedmicaareabout750mzg,800mz/g,?用魂

5、Ianand艇k阵岛眠他加出Ve1.y册出船nera1.,曲后整限ft三迩祖C1.ayS三*Bft%n保固屈板蛆geebacteria1.ce1.1.wa1.1.andstrengthenitsantibaiddtsuqjensionSBvcafiotItectouriSiipehratnttijtiyodynamicdne5erih(hdDuraqueoussuspensionconcentrationcan1.eadanaggregatedoragg1.omerateform,orthesurfaceionicchargescanbeso1.vatedbythepo1.arorganics

6、andwatermo1.ecu1.es网Theaggregationandso1.vationthe!tfeiWttRfi般fhfo曜刷川1。田祖袖碑鲂)hftwhf1.ftta1.届田刖快bf1.kftdpHobviouspropertyofpHdependency.Thephenomenonismain1.yaresu1.tofthec1.aynanop1.atecontaining1.argenumberofnew1.yexposedhydroxy1.functiona1.itiesonthesurface,whichorigina1.1.yexistedInisciriucingcMo

7、hatiiGwi1.htnitttectantfekijhaTjaAthfCtdMrim1.np1.dtfa1.andtbiH)fffiypeprge110fc1.aynanop1.atebyAnnexB(informative)Corre1.ationbetweenquorumquenchingabi1.ityandantibacteria1.performance1.gwiets11iHajfcas!ht(mshb8cftivrtUxita(tethe(ijQMthnsingafiijpta1.rmbta11rtntth3tscta1.materia1.sprovidetheabi1.it

8、ytoquenchquorumsensingsigna1.mo1.ecu1.es.Thequorumquenchingabi1.ity(QQA)canbequantifiedandexpressedinunitsofmeq/100g.Mo1.ecu1.ar1.ywe1.1.-definedsurfactants三gWWStecationic,interaction.SinePrcsur三SI三taeHeristicth1.MP5theQQismeasuredandprobedbytheinteractionofdaynanop1.ateswithsurfactants.Inotherwords

9、,theorigina1.surfactantCMCcandisappearduetothenanop1.ateinteraction.Thenoncova1.entbonding蛆糙窗MeM:哂UOniCSUrfaCtanC初除机能三而削匕端ngintc限眠酎龈郦眠,sur侑阳展渊也interactionwithedgehydroxy1.groupsforanionicsurfactant.曲威Wdifi?IWM&sbac*akur蒯赚Srt蝴腑Mbeco楸SSimU1.瑜姗艇ra巡视册OrcStf1.三1.颗nsingtheeftectivenessofnanop1.ateinteraGU

10、4g-wUUmunicationmo1.ecu1.esofdifferentspecies.Theva1.ueofQQAbyca1.cu1.atingFormu1.a(1)tothecationicsurfactantHDTMA(CT11HaaN(CH3)3Br)and删Hf忠招幽喇&are醐三硼队那部Kate1.ynw明张确认哪砒tin脚/峥叫，ofionicchargesenab1.inganionicexchangereactioninanequiva1.entmannerforthenegative1.ycnargedc1.aynanop1.atewhenquenchingcation

11、icsurfactant.Incontrast,thenotrionicsurfactant,octy1.pheno1.用fe三1.厢5的南9re(VPM舒6*胡卜也疑割胞自值%9QAobhkfef(ard1.f1.etentsCMC.Hence,dependingonthechemica1.natureOfbacteria1.quorumsensingsigna1.s,thenanop)atestendtoexpressadifferentquorumquenchingabi1.itythatsubsequent1.yaffectingthebacteria1.pro1.iferation.

12、1.ft56ttiqhyIMf1.8e忸+ria】CahKth.measurementforthenanop1.ate,squa1.ityandthesubsequentFurther,afternanop1.atequenchingthequorumsensingsigna1.,itcontinuestoadhereontobacteria1.浙曲号椰小殁耻耨防拙淞曲F嫄IkWa1.1.sen艘沁奥旧四弘U1.ar1.曲Rjhty盟涮困*榔dingonewiththepositive1.ychargedcationicsurfactant,isapp1.icab1.eforb1.ockingbacteria1.surfaceforpresumab1.yinhibitingthequorumsensing.Therefore,theovera1.1.antimicrobia1.efficacyiscorre1.ated制中曲M三w哨fe1.W1.entb留Uf