慢性阻塞性肺病.ppt

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1、 GOLD颁布的COPD全球策略 2014年最新更新 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(草案)Global Strategy for Diagnosis,Management and Prevention of COPD,2013:Chapters nDefinition and Overview nDiagnosis and AssessmentnTherapeutic OptionsnManage Stable COPDnManage ExacerbationsnManage ComorbiditiesUpdated 2013 2013 Global Initiat

2、ive for Chronic Obstructive Lung Disease COPD 是一种可以预防和可以治疗的常见疾病,其特征是持续存在的气流受限。气流受限呈进行性发展,伴有气道和肺对有害颗粒或气体所致慢性炎症反应的增加。急性加重和合并症影响患者整体疾病的严重程度。COPD气流受限的气流受限的发发病机制病机制Small Airways Disease Airway inflammation Airway fibrosis,luminal plugs Increased airway resistanceParenchymal Destruction Loss of alveolar a

3、ttachments Decrease of elastic recoilAIRFLOW LIMITATION 2013 Global Initiative for Chronic Obstructive Lung DiseaseCOPD的危的危险险因素因素肺的生长发育性别年龄 呼吸道感染社会经济条件哮喘气道高反应性慢性支气管炎基因有害颗粒暴露 吸烟 职业粉尘，有机物，无机物 室内燃料燃烧和通风不良 室外空气污染 2013 Global Initiative for Chronic Obstructive Lung DiseaseCOPD的危的危险险因素因素 2013 Global Initi

4、ative for Chronic Obstructive Lung DiseaseGlobal Strategy for Diagnosis,Management and Prevention of COPD,2013:Chapters nDefinition and Overview nDiagnosis and AssessmentnTherapeutic OptionsnManage Stable COPDnManage ExacerbationsnManage ComorbiditiesUPDATED 2013 2013 Global Initiative for Chronic O

5、bstructive Lung DiseaseSYMPTOMS chronic coughshortness of breathEXPOSURE TO RISKFACTORS tobaccooccupationindoor/outdoor pollutionSPIROMETRY:Required to establish diagnosisCOPD的的诊诊断断 sputum 2013 Global Initiative for Chronic Obstructive Lung Disease 任何患有呼吸困难、慢性咳嗽或多痰的患者,并且有暴露于危险因素的病史,在临床上需要考虑COPD 的诊断。

6、作出COPD 的诊断需要进行肺功能检查,吸入支气管扩张剂之后FEV1/FVC 0.70 表明存在气流受限,即可诊断COPD。COPD 评估的目的是决定疾病的严重程度,包括气流受限的严重程度,患者的健康状况和未来的风险程度(例如急性加重、住院或死亡),最终目的是指导治疗。2013 Global Initiative for Chronic Obstructive Lung Disease 症状评估 气流受限采用肺功能严重度分级 急性加重风险评估 合并症评估 2013 Global Initiative for Chronic Obstructive Lung Disease*改良英国MRC 呼吸

7、困难指数(modified british medical research council,mMRC)*COPD 评估测试(COPDassessment test,CAT)。症状的症状的评评估估 2013 Global Initiative for Chronic Obstructive Lung DiseaseGlobal Strategy for Diagnosis,Management and Prevention of COPDModified MRC(mMRC)Questionnaire 2013 Global Initiative for Chronic Obstructive

8、Lung Disease气流受限的评估 气流受限程度仍采用肺功能严重度分级,即FEV1 占预计值80%、50%、30%为分级标准。COPD 患者的气流受限的肺功能分级分为4 级(Grades),即:GOLD 1轻度,GOLD 2中度,GOLD 3重度,GOLD 4非常严重。使用支气管扩张剂后，患者肺功能FEV1/FVC 0.70 COPD 分期(Stage)的概念已经被废除 2013 Global Initiative for Chronic Obstructive Lung DiseaseGlobal Strategy for Diagnosis,Management and Prevent

9、ion of COPDClassification of Severity of Airflow Limitation in COPD*In patients with FEV1/FVC 80%predicted GOLD 2:Moderate 50%FEV1 80%predictedGOLD 3:Severe 30%FEV1 50%predictedGOLD 4:Very Severe FEV1 30%predicted*Based on Post-Bronchodilator FEV1 2013 Global Initiative for Chronic Obstructive Lung

10、Disease采用急性加重病史和肺功能评估急性加重的风险,上一年发生2 次或以上的急性加重或FEV1%pred 2 1 0(C)(D)(A)(B)mMRC 0-1CAT 2CAT 10 Symptoms(mMRC or CAT score)2013 Global Initiative for Chronic Obstructive Lung Disease(C)(D)(A)(B)mMRC 0-1CAT 2CAT 10 Symptoms(mMRC or CAT score)If mMRC 0-1 or CAT 2 or CAT 10:More Symptoms(B or D)首先Assess s

11、ymptoms first 2013 Global Initiative for Chronic Obstructive Lung DiseaseRisk(GOLD Classification of Airflow Limitation)Risk(Exacerbation history)2 1 0(C)(D)(A)(B)mMRC 0-1CAT 2CAT 10 Symptoms(mMRC or CAT score)If GOLD 1 or 2 and only 0 or 1 exacerbations per year:Low Risk(A or B)If GOLD 3 or 4 or tw

12、o ormore exacerbations per year:High Risk(C or D)(One or more hospitalizations for COPD exacerbations should be considered high risk.)其次急性加重风险的评估 2013 Global Initiative for Chronic Obstructive Lung DiseaseRisk(GOLD Classification of Airflow Limitation)Risk(Exacerbation history)2 1 0(C)(D)(A)(B)mMRC

13、0-1CAT 2CAT 10 Symptoms(mMRC or CAT score)Patient is now in one offour categories:A:Less symptoms,low riskB:More symptoms,low riskC:Less symptoms,high riskD:More symptoms,high risk综合评估 2013 Global Initiative for Chronic Obstructive Lung DiseaseRisk(GOLD Classification of Airflow Limitation)Risk(Exac

14、erbation history)2 1 0(C)(D)(A)(B)mMRC 0-1CAT 2CAT 10 Symptoms(mMRC or CAT score)2013 Global Initiative for Chronic Obstructive Lung DiseasePatientCharacteristicSpirometric ClassificationExacerbations per yearmMRCCATALow Risk Less SymptomsGOLD 1-2 10-1 2 10CHigh Risk Less SymptomsGOLD 3-4 20-1 2 2 1

15、0 2013 Global Initiative for Chronic Obstructive Lung DiseaseGlobal Strategy for Diagnosis,Management and Prevention of COPDCOPD 中年起病 症状逐年加重 长期吸烟 ASTHMA起病早（常儿童起病）症状变化显著夜间和清晨症状恶化常伴过敏症,鼻炎,和/或湿疹哮喘家族史 2013 Global Initiative for Chronic Obstructive Lung Disease Asthma is a heterogeneous disease,usually c

16、haracterized by chronic airway inflammation.It is defined by the history of respiratory symptoms such as wheeze,shortness of breath,chest tightness and cough that vary over time and in intensity,together with variable expiratory airflow limitation.GINA 2014 COPD is a common preventable and treatable disease,characterized by persistent airflow limitation that is usually progressive and associated with enhanced chronic inflammatory responses in the airways and the lungs to noxious particles or gas