奥曲肽_OctreotideCAS83150-76-9一种模仿天然生长抑素的八肽.docx

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1、奥曲肽/OCtreOtide,CAS83150-76-9,一种模仿天然生长抑素的八肽CASNumber:83150-76-9Formula:C49H66N10010S2Molarmass:1019.25gmol-l奥曲肽/OCtreOtide,同时也以SandOStatin等名字闻名。是一种模仿天然生长抑素的八肽，并且比天然抑素更能抑制生长激素、胰高血糖素和胰岛素。它于1979年由化学家WilfriedBauer首次合成,主要与生长抑素受体SSTR2和SSTR5结合。由于奥曲肽在生理活性上类似生长抑素，它可以：抑制许多激素的分泌，如胃泌素、胆囊收缩素、胰高血糖素、生长激素、胰岛素、分泌素、胰多

2、肽、TSH和血管活性肠肽，减少肠和胰腺的液体分泌，降低胃肠动力并抑制胆囊的收缩，抑制垂体前叶某些激素的作用，inhibitsecretionofmanyhormones,suchasgastrin,cholecystokinin,glucagon,growthhormone,insulin,secretin,pancreaticpolypeptide,TSH,andvasoactiveintestinalpeptide,reducesecretionoffluidsbytheintestineandpancreas,reducegastrointestinalmotilityandinhibitcontractionofthegallbladder,inhibittheactionofcertainhormonesfromtheanteriorpituitary,causevasoconstrictioninthebloodvessels,andreduceportalvesselpressuresinbleedingvarices.Ithasalsobeenshowntoproduceanalgesiceffects,mostprobablyactingasapartialagonistatthemuopioidreceptor.