达夫奈肽.docx

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达夫奈肽/DavunetideCAS211439-12-2,一种源于ADNP的生长因子达夫奈肽DavunetideCAS211439-122是一种鼻内神经肽疗法，来源于活动依赖性神经保护蛋白(ADNP),ADNP是神经胶质细胞在暴露于血管活性肠肽时释放的一种生长因子。其中包含八个氨基酸Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln的肽。该肽具有高效的神经保护活性。Name:达夫奈肽/DavunetideSynonyms:NAP,AL-108ChemicalName:NAPVSIPQ达夫奈肽/Davunetide(AL-108,NAP)isaneightaminoacidpeptidethatpromotesmicrotubulestabilityanddecreasestauphosphorylationinpre-clinicalstudies.SincePSPistightlylinkedtotaupathology,davunetidecouldbeaneffectivetreatmentforProgressivesupranuclearpalsy(PSP).ThegoalsofthisstudyweretoevaluatetheefficacyandsafetyofdavunetideinPSP.