羟丙基甲基纤维素醚HPMC.docx

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1、HydroxypropylMethylCellulose(HPMC)BriefIntroductionHypromelloseorHPMCisanon-ioniccelluloseethermadefromnaturalcottonfiberthroughchemicalprocessing.Theyareodorless,tasteless,non-toxicwhitepowdersthatdissolveincoldwatertoformaclear,viscoussolutionwiththickening,binding,dispersing,emulsifying,film-form

2、ing,suspending,adsorbing,gelling,retainingmoisture,andpropertiesofprotectivecolloids.HPMCcanbewidelyusedinpharmaceuticalexcipientzfood,construction,detergentandotherindustries.PhysicalandChemicalSpecificationTypeMethoxy(WT%)Hydroxypropoxy(WT%)NameintheUSPCASNumberChemicalNameE27.0-30.07.0-12.0Hyprom

3、ellose,Substitutiontype29109004-65-3Cellulose,2-HydroypropylmethyletherF27.0-30.04.0-7.5Hypromellose,Substitutiontype2906K19.0-24.04.0-12.0Hypromellose,Substitutiontype2208AvailablegradesandviscosityspecificationsVitalcelloseTypeViscosity(Cps)RemarkE32-3.5E54-5.52910(E)E65.6-7.0E1512.1-18.0E5040-60E

4、4M3000-5000F5040-602906(F)F4M3000-5000KlOO91-1202208(K)K4M3000-5000KlOOM80000-120000ComplywithUSREPandCRThisproductisamulti-purposepharmaceuticalexcipientthatcanbeusedasathickenedispersantemulsifier,andfilmogen.Asafilmcoatingandbinderinpharmaceuticaltablets,itcansignificantlyimprovethedissolutionrat

5、eofdrugs.Itcanalsobeusedasasuspendingagentinasuspension,asahostmaterialinanophthalmicpreparation,andthelike.GeneralInformationOnMajorFactorsForPharmaceuticalExcipient1) Drugsolubilityisoneofthemostinfluentialfactorsfordesigningadrugreleasepattern.Highlywater-solubledrugsrequirehigheramountsofHPMCint

6、hetablet.2) SuitabletypesofHPMCaretheVitalcelloseEandKgrades,especiallyKgrades,whichhaveacharacteristicofquickhydrationandgelformation.3) ThehigherviscosityofHPMCoramountofHPMCinthetabletcandecreasethedrugreleaserate.Generally,anoptimumcontentofVitalcelloseHPMCinthetabletisatleast20%.Ifthecontentisb

7、elow20%,thereisariskforinitialerosionorexcessdissolutioninthefirststage.4) PreparationmethodalsoaffectsthedissolutionprofileduetothedifferenceofHPMCparticledistributioninthetablet.Inthecaseofwetgranulation,mostofthewatercanbetakenupbyVitalcelloseHPMC,resultingintheseparationofVitalcelloseHPMCandtheo

8、thercomponents.(ie.LargeparticleswithhighVitalcelloseHPMCcontentandungranulateddruginthefineparticlefraction.)Directcompressionmethodscanavoidsuchprocessingfactors.ApplicationofHPMCinfoodHyclroxypropylmethylcellulose(HPMC)hasauiquecombinationofversatility,mainlyreflectthefollowingsuperiorperformance

9、: Reduceoilconsumption:Itcanenhancethelosttastezappearance,texture,moistureandaircharacteristicsduetoreduceoilconsumption; Thickeningproperties:BecauseHPMCcanbeusedinconjunctionwithstarchtoachieveasynergisticeffect,itcanalsoprovideahigherviscositythanthesingleuseofstarchevenatlowdosage; Waterlosscon

10、trol:Itcaneffectivelycontrolthefoodmoisturefromthefreezertoroomtemperaturechange,andreducethedamage,icecrystalsandtexturedeteriorationcausedbyfrozen;TypeApplicationReferenceusageEyEi5Pastrysugarglaze0.1-0.2%Candycoating0.5-6.0%Neticing0.1-0.2%Spiceoilemulsion0.5-3.0%Spicetastingkeeping3.0-8.0%Wrappi

11、ngpowder1.0-2.5%E4MLiquidegg/sugarglaze0.3-1.0%Drymixedsaladseasoner1.0-3.0%Vegetablecream0.1-0.3%Cake0.15-0.8%Bread0.25-0.75%K4MChocolatebiscuit0.2-0.4%Icecreamcone0.2-0.4%Pudding0.2-0.4%Ice-cream0.1-0.5%Cheesestuffing0.2-0.75%Fruitstuffing0.2-0.4%Package25kgDrum1*20feetcontainercanload7.5MTwithpalletizedandIOMTwithoutPalletized

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