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1、重生表皮生长因子联合维生素治疗儿童口腔溃疡的效果及对症状改善情况的影响刘振骸，支方静，董瑜西北大学附属医院/西安市第三医院口腔科，陕西西安710008通讯作者，支方静，E-mail:基金项目，陕西省重点研发计划项目(2018SF-111)【摘要】目的：探究重生表皮生长因子(rhEGF)联合维生素治疗儿童口腔溃疡的效果及对症状改善情况的膨响方法：选取2020年1月-2021年12月西安市第三医院收治的164例口腔溃疡患儿作为试验对象，采用随机数字表法分为两组，时照组(n=82)在常规治疗基础上采用维生素E治疗，试验组(n=82)在常规治疗基础上采用rhEGF联合维生素E治疗，比较两组疗效、症状改
2、善情况、细胞免疫功能、不良反应及复发情况，结果：试验组治疗有效率98.78%(81/82)显著高于对照组91.46%(75/82)(P0.05):试验组止痛时间(1.53O.52)h、溃疡愈合时间(2.16().77)d均短于对照组的(3.18)96)h、(3.460.84)d,视觉模拟评分量表(VAS)钾分(L530.46)分少于对照组的(L970.67)分(P()05):两组治疗后CD3CD4、CD4+/CD8+水平升高，CD8，水平降低(PCD4f(46.275.99)%.CD4)CD8*(1.83O.57)水平显著高于对照组的(7O.357.I3)%、(4O.I65.75)%、(1.4
3、20.34),CD8,(25883.09)%水平显著低于对照组的(28.37325)%(P().05)；治疗期间两组均出现轻度刺激性，其中对照组9例(10.98%),试验组4例(4.88%),两组不良反应发生率比较差异无统计学意义(d=2.089,P=O.148)；随访期间，对照组复发16例(19.51%),试验组复发7例(8.54%),试验组复发率低于对照组(尸=4.096,P=0.043)结论：采用rhEGF联合维生素对口腔溃疡患儿进行治疗可显著提升疗效、改善患儿症状及免疫功能、减少疾病复发情况且具备较高安全性,可用于临床推广。【关键词】小儿：口腔溃疡；重组人表皮生长因子；维生素Effec
4、tofrecombinanthumanepidermalgrowthfactorcombinedwithvitamininthetreatmentofchildrenwithoralulcerandimprovementofsymptomsLiuZhenxia,ZhiFangjing,DongYuDepartmentofStomatology,NorthwesternUniversityAffiliatedHospital/XianThirdHospital,Xian710008.Shaanxi.ChinaCorrespondingauthor:ZhiFangjing,E-mail:Abstr
5、actObjective:Toinvestigatetheeffectofrecombinanthumanepidermalgrowthfactor(rhEGF)combinedwithvitamininthetreatmentofchildrenwithoralulcer,andtheimprovementofsymptoms.Methods:Atotalof164childrenwithoralulceradmittedtoXianThirdHospitalfromJanUary2020toDecember2021wereselected,andrandomlydividedintotwo
6、groups,82CaSeSineach.AIlSUbjeCISweregivenconventionaltreatmentandIreaImenIwithvitaminE.OnIhiSbasis,patientsintheexperimentalgroupweretreatedwithriEGF.Thecurativeeffect,symptomimprovement,cellularimmunefunction,adversereactionsandrecurrencewerecomparedbetweenthetwogroups.Results:Thetreatmentresponser
7、ateintheexperimentalgroupwas98.78%(81/82),significantlyhigherthan91.46%(75/82)inthecontrolgroup(P0.05).Thepainrelieftimeandulcerhealingtimeintheexperimentalgroupl(1.53O,52)hand(2.160.77)dlWereshorterthanthoseinthecontrolgroupl(3.180.96)hand(3.460.84)dl、andtheViSUalAnaIogUeSCaIe(VAS)SCOre(I.530.46)Wa
8、SIOWerIhanIhatOfIheConlrolgroup(1.970.67)(P0.05).Aftertreatment,CD3CD4+andCD47CD8+intheexperimentalgroup1(74.077.29)%.(46.275.99)%and(1.830.57)1Weresignificantlyhigherthanthoseinthecontrolgroup(7O.35713)%J40.16575)%and(L42034)LandCD8*(25.8S3.09)%wassignificantlylowerthanthatinthecontrolgrouDl(28.373
9、.25)%l(,15mnA溃疡为个数单个或2个及以上）比较差异无统计学意义（P005）,见表1。表1两组一般资料比较Table1Comparisonofgeneraldatabetweenthetwogroups组别例数性别例（%）年龄体质量溃疡程度例（）ItemnGendern(%)(Xs,岁)Age(a,s,year)(*s,kg)Weight(s,kg)Severityofulcern(%)男Male女FemaleI度GradeI11度GradeIIIn度GradeI11对照组Controlgroup8245(54.88)37(45.12)4.131.1630.425.3116(19.51)55(67.08)11(13.41)试验组Experimentalgroup2tP82
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